Biomay Distributes Lentivirus Starting Plasmids Off-the-Shelf
Lentivirus starting plasmids are Biomay's most recent off-the-shelf offering, as the company today announced. The set of pre-manufactured lentiviral plasmids are designated for the manufacture of recombinant lentiviral gene transfer vectors. The offered DNA plasmids are immediately available in “RUO” (research use only) quality, whereas GMP-grade lentiviral plasmids will be offered in a few months.
The following lentiviral starting plasmids are now available in RUO quality:
An envelope plasmid providing the envelope glycoprotein derived from the vesicular stomatitis virus glycoprotein G / VSV-G (for broad target cell tropism)
- A packaging plasmid coding for the structural proteins (gag) and functional enzymes (pol)
- A packaging plasmid coding for the gene expression regulators rev
Together with a fourth plasmid – an individual and target-specific transgene plasmid – Biomay's set of lentiviral plasmids represents today's preferred „3rd generation“ approach. This four-plasmid system ensures a high safety standard within the lentiviral vector system.
Today, lentiviral gene transfer vectors are of enormous importance for numerous cell and gene therapies. In particular, T-cells transduced by lentiviral vectors to express chimeric antigen receptors (CAR-T) is state-of-the-art in the clinical development of numerous cancer therapies.
Biomay's recent lentivirus offering perfectly complements last year's launch of numerous adeno-associated virus / AAV plasmids. Later on this year, Biomay will make more lentiviral plasmids available, such as reporter and transgene backbone vectors.
Clients will benefit from Biomay's lentiviral offering:
- Off-the-shelf availability. Biomay's plasmids are immediately available at various aliquot sizes for immediate purchase, accelerating clients' project timelines.
- Excellent plasmid quality: Each plasmid undergoes rigorous quality control testing to ensure purity, stability, performance and batch-to-batch consistency.
- Seamless GMP compliance: Biomay's GMP certification guarantees stringent regulatory requirements, paving the way for smooth and time-saving clinical development.